Typhoid fever is a water and food-borne infectious disease caused by the bacterium, Salmonella enterica. The World Health Organization identifies typhoid fever as a serious public health issue. There are an estimated 22 million new cases reported annually, including over 250,000 deaths, predominantly among preschoolers and school-age children.


Typhoid fever is sometimes difficult to distinguish from other diseases that cause fever, so clinicians make a clinical diagnosis with the aid of laboratory-based diagnostics. In areas where the disease is commonly found, an effective typhoid test must be sensitive, specific, easily accessible, and simple to handle with a short turnaround time.


IDL Biotech offers TUBEX® TF, a rapid and sensitive in vitro diagnostic test for detection of acute typhoid fever. It allows a diagnosis of acute typhoid fever within 10 minutes. The test can easily be performed in any laboratory setting or in the field. A positive result with TUBEX® TF, together with typical clinical symptoms, is a strong indication of typhoid fever.

 

About Typhoid Fever
Typhoid fever is endemic in large parts of Asia, Africa, and Central and South America. The disease causes high fever, flu-like symptoms, and severe symptoms in the digestive system that actuate systemic disease, which is potentially life threatening if not correctly treated. Due to its non-specific clinical indications, patients with typhoid fever are commonly misdiagnosed with malaria, dengue fever, gastroenteritis, or pneumonia. A definitive diagnosis depends on the isolation of S. typhi from bone marrow, blood, or stool, a process that is cumbersome, time-consuming, and, at times, even impossible without reliable tools. Diagnostic alternatives must therefore deliver effective and reliable results, independent of laboratory facilities.


Typhoid fever is normally treated with antibiotics; however studies show that multi-drug resistant (MDR) typhoid strains have become much more common in typhoid high burden communities. Without appropriate antibiotic therapy, typhoid mortality ranges from 12-30 percent.


Another issue affecting the treatment of typhoid is a lack of effective diagnostics. Delayed and inaccurate diagnosis and treatment, sometimes even misdiagnosis, results in increased costs, higher rates of serious complications, and even death. Source: Coalition against typhoid fever , WHO